Pediatric non-alcoholic fatty liver disease: Preventive and therapeutic value of lifestyle intervention

doi:10.3748/wjg.15.6017

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Dec 28, 2009 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2009; 15(48): 6017-6022
Published online Dec 28, 2009. doi: 10.3748/wjg.15.6017

Table 1 Success and failure rates after therapeutic intervention in children with liver-biopsy-proven NAFLD n (%)

	Lifestyle intervention	Vitamin E	Metformin
n	29	25	28
Complete success (all endpoints)	11 (38)	9 (36)	2 (7)
Partial success
Serum ALT normalization	23 (79)	13 (52)	23 (75)
HOMA-IR ≤ 1 restoration	11 (38)	9 (36)	2 (7)
NAS amelioration	19 (65)	17 (68)	16 (57)
Complete failure	4 (14)	8 (32)	2 (7)

NAFLD: Nonalcoholic fatty liver disease; HOMA-IR: Homeostatic model assessment of insulin resistance; NAS: NAFLD activity score; ALT: Alanine transaminase.

Citation: Nobili V, Alisi A, Raponi M. Pediatric non-alcoholic fatty liver disease: Preventive and therapeutic value of lifestyle intervention. World J Gastroenterol 2009; 15(48): 6017-6022
URL: https://www.wjgnet.com/1007-9327/full/v15/i48/6017.htm
DOI: https://dx.doi.org/10.3748/wjg.15.6017