Editorial
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Dec 14, 2009; 15(46): 5761-5769
Published online Dec 14, 2009. doi: 10.3748/wjg.15.5761
Table 1 Geographic distribution and important clinical relevance of HBV genotypes and subgenotypes
GenotypeSubgenotypeGeographic distributionImportant clinical relevanceRef.
AA1AfricaND[13-15]
A2EuropeAcute infection, chronicificaton, more sensitive to interferon treatment than genotype D[11,12,47,48]
A3West AfricaND[13-15]
A4West AfricaND[15]
A5West AfricaND[14,15]
BB1JapanFulminant hepatitis[16]
B2Most of Asia, except KoreaAcute hepatitis, HCC in mostly those younger than 50 years[6,10]
B3IndonesiaND[17,18]
B4Indonesia, VietnamND[18,19]
B5Indonesia, PhilippinesND[17,18,22]
B6IndonesiaND[28]
B7IndonesiaND[17,18]
B8IndonesiaND[17]
CC1South Asia, Southern ChinaHCC and LC[18]
C2Northeast Asia, ChinaHCC and LC mostly in those older than 50 years[6,10]
C3Indonesia, OceaniaND[18,19]
C4AustraliaND[19]
C5Indonesia, PhilippinesND[17,22]
C6Indonesia, PhilippinesND[17,21]
C7IndonesiaND[17]
C8PhilippinesND[20,21]
C9Tibet, ChinaNDUnpublished
DD1 (mainly D)Middle East, the Mediterranean areaChronic liver disease, HCC[13,23-25,37,81]
D2Russia, the Baltic region, IndiaNo apparent clinical relevance[26,32]
D3Indonesia, IndiaOccult HBV infection[17,32]
D4OceaniaND[19]
D5IndiaNo apparent clinical relevance[32]
D6IndonesiaND[33]
D7TunisiaND[34]
ENDWestern and Central AfricaND[13,27,35]
FF IaCentral AmericaHCC[29,36,62]
Chile, Alaska
F IbArgentina, Japan, Venezuela, USA
F IIBrazil, Venezuela, Nicaragua
F IIIVenezuela, Panama, Columbia
F IVArgentina, Bolivia, France
GNDMexico, CanadaND[30,31]
HNDMexicoND[30]
INDVietnam, LaosND[7,8]
JNDJapan (might be from Borneo)HCC[9]