A better parameter in predicting insulin resistance: Obesity plus elevated alanine aminotransferase

doi:10.3748/wjg.15.5598

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Nov 28, 2009 (publication date) through May 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2009; 15(44): 5598-5603
Published online Nov 28, 2009. doi: 10.3748/wjg.15.5598

Table 1 Basic characteristics of subjects, stratified by HOMA_IR (mean ± SD)

	The four sub-groups stratified by HOMA_IR¹				Total
	Q1 (327, 25%)	Q2 (326, 25%)	Q3 (328, 25%)	Q4 (327, 25%)	(1308, 100%)
Age (yr)	38.1 ± 10.0	38.5 ± 9.7	38.7 ± 10.0	39.7 ± 10.3	38.7 ± 10.0
Systolic blood pressure (mmHg)	124.4 ± 13.9	125.8 ± 14.7^a	128.0 ± 15.1^a	132.5 ± 16.0^a	127.7 ± 15.2
Diastolic blood pressure (mmHg)	77.3 ± 10.0	77.6 ± 10.4^a	79.6 ± 11.2^a	82.1 ± 11.7^a	79.1 ± 11.0
Body mass index (kg/m²)	22.8 ± 2.5	23.7 ± 2.5^a	25.1 ± 2.7^a	27.0 ± 3.4^a	24.7 ± 3.3
Waist circumference (cm)	83.6 ± 6.6	85.8 ± 6.1^a	88.9 ± 6.7^a	92.6 ± 7.5^a	87.7 ± 7.5
ALT (U/L)	22.4 ± 16.1	25.5 ± 18.1^a	36.1 ± 48.4^a	40.2 ± 26.4^a	31.0 ± 31.0
AST (U/L)	23.9 ± 11.1	24.2 ± 16.0^a	27.6 ± 20.2^a	28.0 ± 11.5^a	25.9 ± 15.3
Fasting glucose (mg/dL)	95.1 ± 7.6	97.9 ± 7.9^a	99.4 ± 7.9^a	102.5 ± 8.5^a	98.7 ± 8.4
Fasting insulin (U/mL)	3.6 ± 1.0	6.1 ± 0.9^a	8.9 ± 1.1^a	15.8 ± 6.5^a	8.6 ± 5.7
HOMA_IR	0.8 ± 0.2	1.5 ± 0.2^a	2.1 ± 0.2^a	3.9 ± 1.7^a	2.1 ± 1.5
Triglyceride (mg/dL)	113.9 ± 86.8	127.6 ± 86.2^a	157.9 ± 105.7^a	202.8 ± 156.9^a	150.6 ± 117.6
HDL (mg/dL)	52.8 ± 12.5	50.2 ± 9.8^a	47.4 ± 10.7^a	44.4 ± 8.9^a	48.7 ± 11.0

¹The subjects were stratified into four groups according to HOMA_IR; Q1 means the 1st quartile, Q2 means the 2nd, etc. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HDL: High-density lipoprotein; HOMA_IR: Insulin resistance assessed by homeostasis model assessment = fasting insulin (U/mL) × glucose (mmol/L)/22.5.

^aP < 0.05 vs Q1.

Citation: Chen PH, Chen JD, Lin YC. A better parameter in predicting insulin resistance: Obesity plus elevated alanine aminotransferase. World J Gastroenterol 2009; 15(44): 5598-5603
URL: https://www.wjgnet.com/1007-9327/full/v15/i44/5598.htm
DOI: https://dx.doi.org/10.3748/wjg.15.5598