Association between Helicobacter pylori seropositivity and digestive tract cancers

Table 3 Association between H pylori infection and cancer risks

		Odds ratio (95% CI)	P-value	Adjusted odds ratio (95% CI)1	P-value
Oral SCC vs	1st hospital control	0.105 (0.787-1.553)	0.5640	0.961 (0.637-1.449)	0.8494
	2nd hospital control	0.627 (0.445-0.882)	0.0074	0.378 (0.190-0.751)	0.0055
	community control	1.342 (0.952-1.891)	0.0932	1.064 (0.622-1.820)	0.8211
Esophageal SCC vs	1st hospital control	0.470 (0.340-0.648)	< 0.0001	0.454 (0.290-0.710)	0.0005
	2nd hospital control	0.375 (0.277-0.508)	< 0.0001	0.315 (0.203-0.489)	< 0.0001
	community control	0.802 (0.591-1.089)	0.1581	0.472 (0.257-0.865)	0.0151
Gastric adenocarcinoma vs	1st hospital control	2.149 (1.465-3.152)	< 0.0001	2.015 (1.278-3.174)	0.0025
	2nd hospital control	1.715 (1.187-2.479)	0.0041	1.636 (1.071-2.501)	0.0228
	community control	3.672 (2.538-5.312)	< 0.0001	3.060 (1.650-5.674)	0.0004
Colon adenocarcinoma vs	1st hospital control	0.785 (0.549-1.123)	0.1857	0.595 (0.319-1.113)	0.1040
	2nd hospital control	0.882 (0.639-1.219)	0.4476	0.851 (0.581-1.245)	0.4055
	community control	1.888 (1.365-2.613)	0.0001	1.117 (0.612-2.039)	0.7177

¹Compared to KMUH or NTUH controls: adjusting for age (continuous), gender (female vs male), educational levels (≤ primary school vs > high school; junior and high schools vs > high school), cigarette smoking (yes vs no), alcohol consumption (yes vs no) and betel nut chewing (yes vs no); Compared to community controls: Adjusting for the above factors except for betel nut chewing.