Usefulness of a scoring system in the interpretation of histology in neonatal cholestasis

Table 5 Histological features of biliary atresia and other intrahepatic cholestasis (n)

Histological features	Biliary atresia	Intrahepatic cholestasis1
Ductular proliferation
None	1	31
Mild	2	11
Moderate	3	4
Severe	27	2
Bile plug in bile ductules
Absent	10	42
Present	21	7
Porto-portal bridging
None	1	33
< 50% of portal tracts	8	6
> 50% of portal tracts	22	6
Lymphocytic infiltration
Moderate to severe	7	23
Mild	16	24
Absent or mild	10	3
Neutrophilic infiltration
Moderate to severe	3	15
Absent to mild	30	35
Giant cell transformation of hepatocytes
Diffuse	1	16
Only around central vein	13	23
None	19	11
Hepatocytes swelling
Hepatocytes swelling	4	27
Mild/focal	13	22
None	16	1

¹Including cytomegalovirus hepatitis (n = 6), progressive familial intrahepatic cholestasis (n = 4), Alagille syndrome (n = 1), TPN-associated cholestasis (n = 1), hypothyroidism (n = 1), Caroli disease (n = 1), severe perinatal asphyxia (n = 1), idiopathic neonatal hepatitis (n = 35).