Usefulness of a scoring system in the interpretation of histology in neonatal cholestasis

Table 3 Diagnostic accuracy of hepatic histology in patients with neonatal cholestasis-author’s personal interpretation

	Author’s histological diagnoses
	Biliary atresia	Neonatal hepatitis	Paucity bile	Final clinical diagnosis ducts
Biliary atresia	33	30	3
Idiopathic neonatal hepatitis	35	2	33
Cytomegalovirus hepatitis	6	3	3
PFIC	4	1	3
Alagille syndrome	1			1
Parenteral nutrition-associated cholestasis	1		1
Congenital hypothyroidism	1	1
Caroli disease	1		1
Severe asphyxia	1		1
Total	83	37	45	1

PFIC: Progressive familial intrahepatic cholestasis; Sensitivity: TP/(TP + FN) = 30/(30 + 4) = 91%; Specificity = TN/(TN + FP) = 43/(43 + 7) = 86%; Diagnostic accuracy = (TP + TN)/(TP + TN + FN + FP) = (30 + 43)/83 = 88%.