Usefulness of a scoring system in the interpretation of histology in neonatal cholestasis

Table 1 Seven-feature, 15-point histological scoring system devised for the interpretation of liver biopsy materials in neonatal cholestasis¹

Parameter	Histological characterization	Histological grade
Portal ductal proliferation	None	0
	Mild	1
	Moderate	2
	Marked	3
Bile plug in portal ductules	Absent	0
	Present	2
Porto-portal bridging	None	0
	< 50% of portal tracts	1
	> 50% of portal tracts	2
Lymphocytic infiltrate in portal region	None	2
	Mild	1
	Moderate/severe	0
Multinucleated hepatocytes	None	2
	Only around central vein	1
	Diffuse	0
Neutrophils in the infiltrate	Absent or mild	1
	Moderate or marked	0
Hepatocellular swelling	None	2
	Mild/focal	1
	Periportal/diffuse	0

¹The higher the score, the more likely to be biliary atresia.