Comorbidity negatively influences prognosis in patients with extrahepatic cholangiocarcinoma

Table 5 Univariate and multivariate analysis for prognostic survival variables

Variable (n)	Median survival (mo)	95% CI	P (univariate)	P (multivariate)	HR	95% CI
Age at diagnosis
< 73 yr (30)	4.7	0.7-8.7	0.054	-
≥ 73 yr (38)	2.2	0.7-3.8
History of weight loss
No (49)	3.6	0.9-6.2	0.085	-
Yes (19)	2.1	0.5-3.6
CCI score
0-1 (49)	4.7	3.1-6.3	0.017	0.045	3.36	1.0-10.9
≥ 2 (19)	1.4	0.4-2.3
Total bilirubin
< 10 mg/dL (23)	3.6	0.7-6.6	0.583	-
≥ 10 mg/dL (45)	2.3	0-0-4.6
Hemoglobin
≥ 12 g/dL (49)	3.6	1.4-5.7	0.097	-
< 12 g/dL (19)	2.2	0.1-4.4
CA 19-91
< 270 IU/L (15)	8.4	0.0-18.3	0.012	0.089	-	-
≥ 270 IU/L (14)	2.7	0.2-5.2
Primary location
Perihilar (37)	3.1	1.1-5.2	0.994	-
Distal (31)	2.5	0.0-6.3
Lymph node status2
No (46)	2.3	0.0-5.0	0.286	-
Yes (20)	3.6	1.5-5.8
Metastases
No (59)	3.6	1.3-6.1	0.068	-
Yes (9)	0.7	0.3-1.1
Tumor resection
No (49)	2.3	1.4-3.2	0.015	0.005	0.1	0.02-0.51
Yes (19)	8.7	0.0-19.8
Adjuvant therapy3
No (41)	2.1	1.0-3.1	0.129	-
Yes (8)	5.1	2.5-3.2

¹Data available for 29 patients;

²Data available for 66 patients;

³Denotes chemotherapy or brachy-radiotherapy in patients not receiving surgical resection; HR: Hazard ratio; CCI: Charlson comorbidity index.