EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing

Figure 3 Low dose indomethacin effect on chronic gastric ulcer of mice. Chronic gastric ulcers were created by 40% acetic acid as detailed in “Methods”. Then the animals were given indomethacin from day 3 to day 6 at 3 mg/kg per day and the ulcers were assessed after blood withdrawal on day 7 post-surgery. A: Ulcer sizes were measured under dissection microscopy with 16 × magnification; ^bP = 0.006, n = 18; B: Hematology analysis of ulcerated animals on day 7, ^aP < 0.05, n = 6; RBC: Red blood cell; HGB: Hemoglobin; HCT: Hematocrit; C: Hematology of ulcerated animals on day 7, ^aP < 0.05, n = 6; WBC: White blood cells; LYM: Lymphocytes; NEU: Neutrophils; MONO: Monocytes.