Patient-reported outcomes in subjects with neuroendocrine tumors of the pancreas

Table 5 Relationship between demographic and clinical characteristics of the 44 patients who completed the questionnaires and the results of the questionnaires used (in bold the significant associations)

	P
	SF-12 PCS	SF-12 MCS	GHQ-12	STAI Y-1	STAI Y-2	BDI-II
Gender (males vs females)	0.5891	0.6301	0.4802	0.3171	0.2141	0.3873
Age at interview	0.1134	0.0424 (r = 0.309)	0.3511	0.0384 (r = -0.314)	0.3094	0.5255
Disease duration	0.9624	0.7514	0.9121	0.6694	0.7524	0.8565
BMI	0.7664	0.1854	0.1251	0.2414	0.5144	0.7235
Marital status (single vs married)	0.1811	0.0931	0.2372	0.1101	0.5561	0.4433
Diploma (trend from elementary school to university degree)	0.1855	0.9165	0.6483	0.7055	0.3735	0.4053
Job (workers vs retired)	0.2401	0.0321 (-9.4 ± 4.23)	0.2402	0.0541	0.0571	0.2273
Alcohol habit (drinkers vs non-drinkers)	0.4071	0.7451	0.4802	0.6531	0.7241	0.9303
Smoking habit (smokers vs non-smokers)	0.3491	0.4651	0.2942	0.1241	0.1221	0.6013
Comorbidities (present vs absent)	0.6511	0.9231	1.0002	0.4351	0.2021	0.4023
Non-disease specific drugs (yes vs no)	0.0321 (-8.7 ± 3.9)	0.3221	0.0852	0.3691	0.1521	0.1403
Previous surgery not due to neuroendocrine tumors (yes vs no)	0.7751	0.2381	0.2412	0.4391	0.4371	0.3213
Surgery due to pancreatic neuroendocrine tumors (yes vs no)	0.0491 (8.1 ± 4.0)	0.7781	0.6692	0.9871	0.8801	0.9573
Disease status (disease free patients vs patients having lymph node involvement or liver metastases)	0.8751	0.4541	1.0002	0.3001	0.1691	0.1053
Specific treatment (yes vs no)	0.8161	0.4541	0.7222	0.9251	0.7331	0.9853
Pain in the last month (present vs absent)	0.1521	0.3711	0.0752	0.0461 (7.4 ± 3.6)	0.0491 (6.7 ± 3.3)	0.1903
Dyspepsia (present vs absent)	0.1151	0.0251 (-8.7 ± 3.8)	0.7282	0.1991	0.1951	0.01536
Diabetes (present vs absent)	0.9081	0.2631	0.4572	0.8831	0.5811	0.9383

¹One-way ANOVA (effect estimates; mean ± SE);

²Fisher exact test;

³Liner-by-linear association chi-square (frequencies);

⁴Pearson correlation (regression coefficient; r);

⁵One-way linear term ANOVA;

⁶Frequency of dyspepsia: according to BDI-II: absence of depression (score ≤ 13) 10/27 (37.0%); mild depression (score 14-19) 8/9 (88.9%); moderate depression (score 20-28) 6/8 (75.0%). In order to quantify the relationships, the various effect estimates - evaluated according to the statistical analysis applied - have been reported in parentheses.