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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Oct 28, 2009; 15(40): 5058-5066
Published online Oct 28, 2009. doi: 10.3748/wjg.15.5058
Published online Oct 28, 2009. doi: 10.3748/wjg.15.5058
Table 5 Haematological toxicity and UGT1A1 status (per cycle analysis) cycles (%)
| WT (6/6) | (6/7, 7/7) | χ² test | |||||
| Grade 0 | Grade 1-2 | Grade 3-4 | Grade 0 | Grade 1-2 | Grade 3-4 | ||
| Leucocytes | 69 (61.1) | 43 (38.1) | 1 (0.9) | 102 (52.8) | 85 (44.0) | 6 (3.1) | P > 0.05 |
| Neutropenic fever | 113 (100.0) | - | - | 191 (98.9) | 1 (0.5) | 1 (0.5) | P > 0.05 |
| Anaemia | 30 (26.5) | 80 (70.8) | 3 (2.7) | 47 (24.3) | 142 (73.6) | 4 (2.1) | P > 0.05 |
| Thrombocytes | 89 (78.8) | 23 (20.4) | 1 (0.9) | 157 (81.3) | 36 (18.7) | - | P > 0.05 |
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Citation: Schulz C, Heinemann V, Schalhorn A, Moosmann N, Zwingers T, Boeck S, Giessen C, Stemmler HJ.
UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer. World J Gastroenterol 2009; 15(40): 5058-5066 - URL: https://www.wjgnet.com/1007-9327/full/v15/i40/5058.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.5058