UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer

doi:10.3748/wjg.15.5058

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Oct 28, 2009 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2009; 15(40): 5058-5066
Published online Oct 28, 2009. doi: 10.3748/wjg.15.5058

Table 3 Response to treatment with regard to UGT1A1 status n (%)

	*WT (6/6)*	*(6/7, 7/7)*	All	χ*² test [WT vs (6/7, 7/7)]*
CR	3 (8.1)	7 (11.5)	10 (10.2)
PR	13 (35.1)	20 (32.8)	33 (33.7)
SD	11 (29.7)	29 (47.5)	40 (40.8)
PD	7 (18.9)	5 (8.2)	12 (12.2)
NA	3 (8.1)	-	3 (3.1)
OR	16 (43.2)	27 (44.3)	43 (43.9)	P > 0.05
DCR	27 (73.0)	56 (91.8)	83 (84.7)	P < 0.05

CR: Complete remission; PR: Partial remission; SD: Stable disease; PD: Progressive disease; OR: Overall response rate (CR + PR); DCR: Disease control rate (CR + PR + SD); NA: Not available.

Citation: Schulz C, Heinemann V, Schalhorn A, Moosmann N, Zwingers T, Boeck S, Giessen C, Stemmler HJ. UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer. World J Gastroenterol 2009; 15(40): 5058-5066
URL: https://www.wjgnet.com/1007-9327/full/v15/i40/5058.htm
DOI: https://dx.doi.org/10.3748/wjg.15.5058