Protein interaction network related to Helicobacter pylori infection response

Table 5 List of proteins with only a large BC and their functions

Protein name	Function
HMGB1	Binds to preferentially single-stranded DNA and unwinds double-stranded DNA
BTK	Plays a crucial role in B-cell ontogeny
CSNK2A1	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates
CXCR4	Transduces a signal by increasing the intracellular calcium ion level
CCL4	Monokine with inflammatory and chemokinetic properties
RAC2	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytosis of apoptotic cells and epithelial cell polarization. Seems to be involved in the regulation of NADPH oxidase