Protein interaction network related to Helicobacter pylori infection response

Table 3 List of proteins with both a large BC and degree, and their functions

Protein name	Function
RELA/NF-κB3	NF-κB is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis
MAPK8	Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity
NFKBIA	Inhibits the activity of dimeric NF-κB/REL complexes by trapping REL dimers in the cytoplasm, masking their nuclear localization signals
HCK	May serve as part of a signaling pathway coupling the Fc receptor to activation of the respiratory burst. May also contribute to neutrophil migration and regulate the degranulation process of neutrophils
PTPRC	Required for T-cell activation through the antigen receptor
ITGB2	Receptor for ICAM1, ICAM2, ICAM3 and ICAM4
TLR4	Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-κB activation, cytokine secretion and the inflammatory response
PLAT	Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events
TRAF4	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases
MAP2K1	Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases
TLR2	Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components
STAT6	Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signaling