Expression of thymidylate synthase and glutathione-s-transferase π in patients with esophageal squamous cell carcinoma

Table 1 Relationship between TS and clinicopathological characteristics of ESCC

Factor	n	(+)	(-)	Positive (%)	P value
Sex
M	86	40	46	46.51
F	16	3	13	18.75	0.039
Age (yr)
< 60	58	27	31	46.55
≥ 60	44	16	28	36.36	0.302
Histological grade
Well	32	7	25	21.88
Moderate & poor	70	36	34	51.43	0.005
Lymph node metastasis
(-)	55	24	31	43.64
(+)	47	19	28	40.43	0.743
Location1
Upper	11	4	7	36.36
Middle	55	22	33	40.00
Lower	36	17	19	47.22	0.822
T Stage
T0-1	7	4	3	57.14
T2-4	95	39	56	41.04	0.405

¹Location: Upper, upper intra-thoracic esophagus; Middle, middle intra-thoracic esophagus; Lower, lower intra-thoracic esophagus. TS: Thymidylate synthase; ESCC: Esophageal squamous cell carcinoma.