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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Sep 7, 2009; 15(33): 4137-4142
Published online Sep 7, 2009. doi: 10.3748/wjg.15.4137
Published online Sep 7, 2009. doi: 10.3748/wjg.15.4137
Figure 2 The mechanism of insulin secretion reduction due to glucose toxicity.
DNA binding capacity of PDX-1 decreases as a result of oxidative stress caused by hyperglycemia, while insulin biosynthesis and secretion also decrease. Black arrows indicate pathway, grey arrows indicate increase or decrease. PDX-1: Pancreatic duodenal homeobox-1.
- Citation: Kawahito S, Kitahata H, Oshita S. Problems associated with glucose toxicity: Role of hyperglycemia-induced oxidative stress. World J Gastroenterol 2009; 15(33): 4137-4142
- URL: https://www.wjgnet.com/1007-9327/full/v15/i33/4137.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.4137