Bile acids as endogenous etiologic agents in gastrointestinal cancer

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Jul 21, 2009 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2009; 15(27): 3329-3340
Published online Jul 21, 2009. doi: 10.3748/wjg.15.3329

Table 5 Bile acids induce apoptosis in colon cells

Cells/tissues	Bile acid(s) that induced apoptosis	Ref.
Biopsies from normal human colonic mucosa	DCA	[135–139]
Colon adenoma cell lines (AA/C1 and RG/C2), and carcinoma cell line (PC/JW/F1)	DCA	[140]
Cultured human adenocarcinoma cells (HT-29 and CaCo-2)	DCA	[141 142]
Cultured human adenocarcinoma cells (HCT-116)	DCA, CDCA	[130 143–146]
	DCA	[116 147–149]
Cultured human adenocarcinoma cells (HT-29)	DCA	[114]
Cultured human adenocarcinoma cells (HT-29 and HCT-116)	DCA	[150]
	DCA	[128]
	DCA, LCA, CDCA	[151]
Cultured human adenocarcinoma cells (HT-29) and human fetal colonic mucosal cells (FHC)	DCA, LCA, CA, CDCA	[152]
Cultured human adenocarcinoma cells (HT-29, SW480, SW620)	DCA, CDCA	[153 154]
Cultured human adenocarcinoma cells [HCT-116 (p53⁺) and HCT-15 (p53^-)]	DCA	[127]
Cultured human adenocarcinoma cells (HCT-116SA apoptosis-sensitive and HCT-116RB, HCT-116RC and HCT-116RD apoptosis resistant)	DCA	[155]
Human colonic mucosal samples from surgical resections	DCA	[156]

Citation: Bernstein H, Bernstein C, Payne CM, Dvorak K. Bile acids as endogenous etiologic agents in gastrointestinal cancer. World J Gastroenterol 2009; 15(27): 3329-3340
URL: https://www.wjgnet.com/1007-9327/full/v15/i27/3329.htm
DOI: https://dx.doi.org/10.3748/wjg.15.3329