Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease

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Jul 7, 2009 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2009; 15(25): 3134-3141
Published online Jul 7, 2009. doi: 10.3748/wjg.15.3134

Table 4 Total serum bile acids and conjugates in CD, UC and control cohorts

	Control	CD	UC
Total BAs (nmol/L)	3752.0	2563.3^a	3010.2
Total unconjugated BAs¹ (nmol/L)	644.1	631.1	471.0^a^b
Total conjugated BAs (nmol/L)	2763.6	1526.9^a	2529.6^b
Total BA glycoconjugates (nmol/L)	2423.6	1407.6^a	2298.9^b
Total BA glycoconjugates/total conjugated BAs (%)	87.4	95.7^a	92.7^a^b
Total BA tauroconjugates¹ (nmol/L)	344.2	68.0^a	145.0^a^b
Total BA tauroconjugates/ total conjugated BAs (%)	12.6	4.3^a	7.3^a^b
(Deoxy-BAs + TLCA + GLCA + LCA)/total BAs (%)	83.7	84.1	77.4^a^b

Control: n = 310; CD: n = 73, n = 197¹; UC: n = 44, n = 161¹. Data expressed as medians.

^aP < 0.05 vs control,

^bP < 0.05 vs CD (Mann-Whitney U test).

Citation: Gnewuch C, Liebisch G, Langmann T, Dieplinger B, Mueller T, Haltmayer M, Dieplinger H, Zahn A, Stremmel W, Rogler G, Schmitz G. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J Gastroenterol 2009; 15(25): 3134-3141
URL: https://www.wjgnet.com/1007-9327/full/v15/i25/3134.htm
DOI: https://dx.doi.org/10.3748/wjg.15.3134