Review
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Jul 7, 2009; 15(25): 3086-3098
Published online Jul 7, 2009. doi: 10.3748/wjg.15.3086
Table 2 Main criteria for an AHF animal model (according to Terblanche and Hickman (1991)
ReversibilitySuitable treatment may reverse and improve survival
ReproducibilityReproducible end-points are required to standardize the model
Death from liver failureShould reflect biochemical, histological and clinical changes including death from AHF
Therapeutic windowTime for treatment should be available between insult and death
Adequate animal sizeSize large enough to allow blood and tissue analysis to take place serially
Minimal hazard to personnelMinimum risk for operators and associated staff