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World Journal of Gastroenterology
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1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Jun 28, 2009; 15(24): 2960-2974
Published online Jun 28, 2009. doi: 10.3748/wjg.15.2960
Table 3 Drugs that may need to be administered at reduced doses in patients with liver cirrhosis[187]
Drugs with high first-pass effectDrugs metabolized mainly by
CYP 1A2CYP3A4CYP2C9
AmitriptylineAcetaminophenQuinidineDiclofenac
BromocriptineCaffeineAmiodaroneIbuprofen
DiltiazemMexiletineLidocaineMefenamic acid
Flumazenil(R)-WarfarinMidazolamTolbutamide
FluorouracilImipramineDiazepamPhenytoin
ImipramineTheophyllineAmitriptylinePhenobarbital
Isosorbide dinitratePropranololImipramine(S)-Warfarin
LabetalolTamoxifenCarbamazepineLosartan
LidocaineEstradiol(R)-WarfarinPiroxicam
MorphineErythromycin
NifedipineClarithromycin
Pentazocine
Propranolol
Verapamil
Full Size Table
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