Editorial
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Jun 14, 2009; 15(22): 2693-2700
Published online Jun 14, 2009. doi: 10.3748/wjg.15.2693
Table 1 Summary of published studies evaluating the use of Tc-99m HMPAO WBC in IBD
StudynStudy designSensitivitySpecificity
Adult population
Sciarretta et al[23]103Known active CD compared with colonoscopy95%100%
Mairal et al[50]27Known IBD compared with In-111 HIG100%85%
Giaffer et al[13]31Suspected IBD compared with In-111 oxine labeled leukocytes85% at 40 min 94% at 120 min87% at 40 min 71% at 120 min
Kolkman et al[33]32Known IBD compared with CT79% for CD 81% for UC98% for CD 86% for UC
Molnár et al[34]28Known active CD compared with spiral CT76.1%91%
Almer et al[25]48Known active CD with small bowel inflammation compared with intraoperative small bowel enteroscopy and laparotomy findings85%81%
Pediatric population
Charron et al[40]215Acute intestinal inflammation in patients with and without IBD90%97%
Cucchiara et al[38]48Suspected IBD compared with colonoscopy76.2%NA
Charron et al[42]130Exclude inflammation in suspected IBD compared with colonoscopy94%99%
Alberini et al[37]28Known IBD compared with endoscopy, ultrasonography and contrast radiology75%92%
Charron et al[35]313Known IBD compared with colonoscopy92%94%