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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Jun 7, 2009; 15(21): 2595-2601
Published online Jun 7, 2009. doi: 10.3748/wjg.15.2595
Published online Jun 7, 2009. doi: 10.3748/wjg.15.2595
Table 4 Methylation and clinical data of WIF-1 genes in HCC and adjacent non-cancerous tissues
| Clinical data | Methylation in HCC | Methylation in adjacent non-cancerous tissues | ||||
| Negative | Positive | P | Negative | Positive | P | |
| Sex | ||||||
| Male | 17 | 10 | 0.659 | 23 | 4 | 1.000 |
| Female | 3 | 3 | 5 | 1 | ||
| Age (yr) | ||||||
| < 60 | 7 | 5 | 1.000 | 17 | 3 | 1.000 |
| ≥ 60 | 13 | 8 | 11 | 2 | ||
| Child | ||||||
| A | 17 | 12 | 1.000 | 24 | 5 | 1.000 |
| B | 3 | 1 | 4 | 0 | ||
| AFP (ng/mL) | ||||||
| < 20 | 11 | 8 | 1.000 | 16 | 3 | 1.000 |
| ≥ 20 | 9 | 5 | 12 | 2 | ||
| Number of tumor | ||||||
| Single | 14 | 10 | 1.000 | 21 | 3 | 0.597 |
| Multiple | 6 | 3 | 7 | 2 | ||
| Tumor diameter (cm) | ||||||
| < 3 | 2 | 3 | 1.000 | 5 | 0 | 0.569 |
| ≥ 3 | 18 | 10 | 23 | 5 | ||
| HBsAg | ||||||
| (+) | 20 | 9 | 0.017 | 24 | 5 | 1.000 |
| (-) | 0 | 4 | 4 | 0 | ||
| Hepatocirrhosis | ||||||
| (+) | 18 | 7 | 0.035 | 21 | 4 | 1.000 |
| (-) | 2 | 6 | 7 | 1 | ||
| False capsule | ||||||
| (+) | 18 | 10 | 0.360 | 24 | 4 | 1.000 |
| (-) | 2 | 3 | 4 | 1 | ||
| Tumor thrombus | ||||||
| (+) | 1 | 2 | 0.547 | 2 | 1 | 0.400 |
| (-) | 19 | 11 | 26 | 4 | ||
| Edmonson stage | ||||||
| I/II | 16 | 12 | 0.625 | 23 | 5 | 0.569 |
| III | 4 | 1 | 5 | 0 | ||
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Citation: Ding Z, Qian YB, Zhu LX, Xiong QR. Promoter methylation and mRNA expression of
DKK-3 andWIF-1 in hepatocellular carcinoma. World J Gastroenterol 2009; 15(21): 2595-2601 - URL: https://www.wjgnet.com/1007-9327/full/v15/i21/2595.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.2595