Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma

Table 3 Methylation and clinical data of DKK-3 genes in HCC and adjacent non-cancerous tissues

Clinical data	Methylation in HCC			Methylation in adjacent non-cancerous tissues
	Negative	Positive	P	Negative	Positive	P
Sex
Male	12	15	1.000	21	6	1.000
Female	3	3		5	1
Age (yr)
< 60	13	7	0.011	17	3	0.393
≥ 60	2	11		9	4
Child
A	12	17	0.308	23	6	1.000
B	3	1		3	1
AFP (ng/mL)
< 20	7	10	0.308	15	3	0.674
≥ 20	8	8		11	4
Number of tumor
Single	11	13	1.000	20	4	0.358
Multiple	4	5		6	3
Tumor diameter (cm)
< 3	2	3	1.000	3	2	1.000
≥ 3	13	15		23	5
HBsAg
(+)	15	14	0.108	23	6	1.000
(-)	0	4		3	1
Hepatocirrhosis
(+)	15	10	0.004	20	5	1.000
(-)	0	8		6	2
False capsule
(+)	14	14	0.346	23	5	0.282
(-)	1	4		3	2
Tumor thrombus
(+)	1	2	1.000	3	0	1.000
(-)	14	16		23	7
Edmonson stage
I/II	13	15	1.000	22	6	1.000
III	2	3		4	1