©2009 The WJG Press and Baishideng.
World J Gastroenterol. Jun 7, 2009; 15(21): 2570-2578
Published online Jun 7, 2009. doi: 10.3748/wjg.15.2570
Published online Jun 7, 2009. doi: 10.3748/wjg.15.2570
Table 4 Pathophysiology of growth failure in children with IBD
| Ethiopathogenesis | Mechanism |
| Energy and nutrient deficiencies[30] | Deficits of energy, macronutrients and micronutrients |
| Inflammation/proinflammatory cytokines[31] | Anorexigenic effect |
| GH-IGF1 axis effects | |
| Bone metabolism disturbance | |
| Hypermetabolic/catabolic effects | |
| Disease severity and disease location[3233] | Severe disease |
| Jejunal localization | |
| Abnormal bone metabolism[34] | Effect of pro-inflammatory cytokines |
| GH-IGF1 axis dysfunction | |
| Calcium and vitamin D deficiency | |
| Delayed sexual maturation | |
| Corticosteroids | |
| Delayed onset of sexual maturation[35] | Hypogonadism |
| Abnormal IGF1 axis[36] | Low IGF1 and IGF1-BP |
| Proinflammatory cytokines | |
| Drugs[28] | Corticosteroids |
- Citation: Hartman C, Eliakim R, Shamir R. Nutritional status and nutritional therapy in inflammatory bowel diseases. World J Gastroenterol 2009; 15(21): 2570-2578
- URL: https://www.wjgnet.com/1007-9327/full/v15/i21/2570.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.2570