Human herpesvirus 6 infections after liver transplantation

Table 3 Antiviral molecules and their activity against HHV-6

Antiviral drug	In vitro activity	In vivo activity1	Mechanism of antiviral resistance
Acyclovir[7381]	No	No
Ganciclovir[66–6870–72]	Yes	Yes	Mutation in U38 DNA polymerase
			Mutation in U69 phosphotransferase
Foscarnet[6582–85]	Yes	Yes2	Mutation in U38 DNA polymerase
Cidofovir[768695]	Yes	Yes	Mutation in U38 DNA polymerase
Maribavir[8788]	No	Not available
Cyclopropavir[89]	Yes	Not available
CMV 423[91]	Yes3	Not available
HDP-CDV[90]	Yes3	Not available
3 Deaza-HPMPA[92]	Yes	Not available

CMV 423: A New anti-CMV (Cytomegalovirus) molecule (2-chloro 3-pyridine 3-yl 5,6,7,8-tetrahydroindolizine 1-carboxamide); HDP-CDV: Hexadecyloxopropyl-cidofovir; 3 Deaza-HPMPA: (S)-9-[5-Hydroxy-2-(phosphonomethoxy) propyl]-3 deazaadenosine.

¹Based on very limited studies and case reports;

²Combination of foscarnet with ganciclovir or cidofovir has been reported and can be efficacious;

³Activity in vitro demonstrated against HHV6-A.