Non-invasive biomarkers for monitoring the fibrogenic process in liver: A short survey

Table 2 Class II biomarkers of liver fibrogenesis

Index	Parameters	Chronic liver disease	Sensitivity (%)	Specificity (%)
PGAA-Index	Prothrombin time, γGT, apolipoprotein A1, α2-macroglobulin	Alcohol	79	89
Bonacini-Index	ALT/AST-ratio, INR, platelet count	HCV	46	98
Sheth-Index	AST/ALT (De Ritis)	HCV	53	100
Park-Index		HCV	47	96
PGA-Index	Prothrombin time, γGT, apolipoprotein A1	Mixed	91	81
Fortunato-Score	Fibronectin, prothrombin time, PCHE, ALT, Mn-SOD, β-NAG	HCV		94
Fibrotest (Fibro-Score)	Haptoglobin, α2-macroglobulin, apolipoprotein A1, γGT, bilirubin	HCV	75	85
		HBV
Pohl-Score	AST/ALT-ratio, platelet count	HCV	41	99
Actitest	Fibrotest + ALT	HCV
Forns-Index	Age, platelet count, γGT, cholesterol	HCV	94	51
Wai-Index (APRI)	AST, platelet count	HCV	89	75
Rosenberg-Score (ELF-Score)	PIIINP, hyaluronan, TIMP-1	Mixed	90	41
Patel-Index (FibroSpect)	Hyaluronan, TIMP-1, α2-macroglobulin	HCV	77	73
Sud-Index (fibrosis probability-index, FPI)	Age, AST, cholesterol, insulin resistance (HOMA), past alcohol intake	HCV	96	44
Leroy-Score	PIIINP, MMP-1	HCV	60	92
Fibrometer test	Platelet count, prothrombin index, AST, α2-macro-globulin, hyaluronan, urea, age	Mixed	81	84
Hepascore	Bilirubin, γGT, hyaluronan, α2-macroglobulin, age, gender	HCV	63	89
Testa-Index	Platelet count/spleen diameter-ratio	HCV	78	79
FIB-4	Platelet count, AST, ALT, age	HCV/HIV	70	74
FibroIndex	Platelet count, AST, γ-globulin	HCV	38	97

GGT: γ-glutamyltransferase; PIIINP: N-terminal propeptide of type III procollagen; TIMP: Tissue inhibitors of metalloproteinases; MMP: Matrix metalloproteinases; β-NAG: N-acetyl-β-glucosaminidase; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; INR: International normalized ratio.