No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk

Table 2 Odds ratios for individual SNPs and SNP by NSAID use interactions

SNP	Case/control	Crude		Adjusted		Stratified by NSAID use
		OR (95% CI)	P1	OR (95% CI)	P2	Regular	None	P3
COX2
rs2066826			0.45		0.34			0.41
GG	314/370	Ref		Ref		Ref	Ref
AG	98/99	1.17 (0.85, 1.60)		1.23 (0.88, 1.72)		1.05 (0.68, 2.64)	1.52 (0.82, 2.83)
AA	8/12	0.79 (0.32, 1.95)		1.06 (0.41, 2.73)		0.52 (0.10, 2.64)	1.96 (0.30, 12.62)
rs2206593			0.049		0.25			0.47
GG	382/417	Ref		Ref		Ref	Ref
AG	39/63	0.68 (0.44, 1.03)		0.69 (0.44, 1.07)		0.64 (0.36, 1.13)	0.89 (0.42, 1.90)
AA	0/2	-		-		-	-
rs5277			0.97		0.58			0.76
CC	310/353	Ref		Ref		Ref	Ref
CG	104/119	1.00 (0.73, 1.35)		0.90 (0.65, 1.25)		0.90 (0.59, 1.36)	0.86 (0.48, 1.54)
GG	7/8	1.00 (0.36, 2.78)		0.80 (0.27, 2.36)		0.52 (0.09, 2.95)	1.85 (0.32, 10.56)
rs689470			0.87		0.79			> 0.99
GG	380/440	Ref		Ref		Ref	Ref
AG	35/36	1.13 (0.69, 1.83)		1.15 (0.66, 2.02)		1.13 (0.54, 2.35)	1.59 (0.60, 4.22)
AA	4/4	1.16 (0.29, 4.66)		1.60 (0.26, 9.70)		-	2.38 (0.13, 43.43)
rs4648310			0.95		0.67			0.50
AA	405/462	Ref		Ref		Ref	Ref
AG	17/19	1.08 (0.55, 2.12)		1.07 (0.53, 2.19)		1.25 (0.48, 3.23)	0.69 (0.21, 2.27)
GG	0/1	-		-		-	-
rs5275			0.34		0.51			0.89
AA	176/216	Ref		Ref		Ref	Ref
AG	189/199	1.17 (0.88, 1.55)		1.17 (0.87, 1.58)		1.14 (0.78, 1.67)	1.04 (0.60, 1.79)
GG	56/65	1.06 (0.70, 1.59)		1.22 (0.79, 1.88)		0.98 (0.57, 1.71)	1.79 (0.78, 4.12)
rs689466			0.46		0.69			0.99
AA	275/297	Ref		Ref		Ref	Ref
AG	138/168	0.89 (0.67, 1.17)		0.86 (0.64, 1.15)		0.91 (0.62, 1.33)	0.83 (0.48, 1.42)
GG	9/15	0.65 (0.28, 1.51)		0.65 (0.26, 1.60)		0.75 (0.26, 2.17)	0.69 (0.11, 4.45)
rs20417			0.41		0.20			0.44
GG	291/343	Ref		Ref		Ref	Ref
CG	119/121	1.16 (0.86, 1.56)		1.25 (0.91, 1.71)		1.17 (0.78, 1.74)	1.39 (0.78, 2.47)
CC	11/15	0.86 (0.39, 1.91)		0.97 (0.43, 2.20)		0.46 (0.14, 1.54)	3.12 (0.57, 17.15)
rs2745557			0.61		0.41			0.18
GG	287/321	Ref		Ref		Ref	Ref
AG	120/141	0.95 (0.71, 1.27)		0.93 (0.69, 1.27)		1.04 (0.70, 1.54)	0.77 (0.43, 1.38)
AA	13/19	0.76 (0.37, 1.58)		1.01 (0.48, 2.14)		1.49 (0.60, 3.67)	0.34 (0.07, 1.68)
UGT1A6
rs1105879			0.46		0.28			0.93
AA	191/206	Ref		Ref		Ref	Ref
AC	167/209	0.86 (0.65, 1.14)		0.84 (0.63, 1.14)		0.84 (0.57, 1.23)	0.86 (0.50, 1.48)
CC	64/66	1.05 (0.70, 1.55)		1.07 (0.71, 1.64)		1.20 (0.70, 2.06)	1.07 (0.50, 2.32)
rs2070959			0.21		0.21			0.93
AA	208/207	Ref		Ref		Ref	Ref
AG	154/206	0.78 (0.59, 1.03)		0.78 (0.58, 1.04)		0.76 (0.52, 1.12)	0.82 (0.48, 1.42)
GG	59/57	1.08 (0.72, 1.63)		1.11 (0.72, 1.72)		1.26 (0.72, 2.23)	1.04 (0.47, 2.29)

¹P-value of SNP in best fitting genetic model in the unadjusted logistic regression; ²P-value of SNP in best fitting genetic model in the full multivariate logistic regression; ³P-value of interaction of SNP in best fitting genetic model with regular NSAID use in the logistic regression; ^aP < 0.05.