No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk

Table 1 Population characteristics n (%)

	Case (n = 422)	Control (n = 481)	P1
Age (mean ± SD) (yr)2	62.9 ± 10.6	57.9 ± 11.1	< 0.0001
Gender			0.0002
Female	203 (50.5)	304 (64.1)
Male	199 (49.5)	178 (35.9)
Race
Caucasian	378 (93.6)	449 (93.2)	0.35
African-American	21 (4.4)	21 (5.2)
Other	12 (2.5)	5 (1.2)
BMI (mean ± SD) (kg/m2)	29.2 ± 6.2	28.1 ± 6.1	< 0.0001
Family history3			0.0011
Yes	94 (24.0)	71 (15.2)
No	297 (76.0)	395 (84.8)
NSAID use			0.14
Regular	235 (64.2)	306 (69.1)
Irregular/none	131 (35.8)	137 (30.9)
Physical activity			0.008
None/low	111 (29.1)	113 (24.7)
Moderate	106 (27.8)	98 (21.4)
High	165 (43.2)	246 (53.8)
Regular alcohol use			0.04
Ever	134 (34.8)	191 (41.7)
Never	251 (65.2)	267 (58.3)
Smoking			0.88
Ever	207 (53.6)	248 (54.2)
Never	179 (46.4)	210 (45.9)

¹P-value of significance difference between cases and controls in χ² test (discrete variables and genotypes) or t-test (continuous);

²Age at diagnosis for cases, and age at questionnaire completion for controls;

³Family history of first-degree relatives with colorectal cancer.