C-type natriuretic-peptide-potentiated relaxation response of gastric smooth muscle in streptozotocin-induced diabetic rats

Figure 2 The sensitivity of gastric smooth muscle to CNP. A, B: The row traces gastric smooth muscle spontaneous contractions in response to CNP in normal and diabetic rats; C-E: Summary of the contractility in response to CNP in normal and diabetic rats. CNP induced relaxation of gastric antral smooth muscle in control and diabetic rats (A, B). However, CNP-induced inhibition of spontaneous contraction was potentiated in diabetic rats, and the amplitude (C, n = 8, ^bP < 0.01) and frequency (D, n = 8, ^dP < 0.01) of spontaneous contraction were more potentially suppressed by CNP in diabetic rats. The inhibition time of CNP of spontaneous contraction was significantly prolonged in diabetic rats (E, n = 8, ^fP < 0.01).