High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells

Figure 4 Dose-dependence of miR-196a promoted effects. A: miR-196a decreases HoxA7, HoxB8, HoxC8 and HoxD8 mRNA levels with a dose-dependent and gene-specific character; B: miR-196a inhibits cancer cell adhesion to plastic covers in a dose-dependent manner; C: Biological features of HoxB8, HoxC8 and HoxD8 as reported in literature. HoxB8 exerts an oncogenic effect, while HoxD8 might have tumor-suppressive relevance. For HoxC8 both, pro-oncogenic and anti-oncogenic features, have been reported.