Hyperferritinemia is a risk factor for steatosis in chronic liver disease

Table 1 Demographic, laboratory and histological features of 124 patients (mean ± SD)

Variable
Mean age (yr)	53.3 ± 1.2
Age (yr), n (%)
≤ 50	51 (41.2)
> 50	73 (58.8)
Sex, n (%)
Male	90 (72.5)
Female	34 (27.5)
BMI (kg/m2)
< 25	74 (59.6)
25-29.9	50 (40.3)
ALT-UNL	3.0 ± 1.0
AST-UNL	2.0 ± 1.0
GGT-UNL	2.0 ± 0.3
Ferritin (ng/mL)	799.7 ± 75.6
Serum iron (&mgr;g/dL)	126 ± 6.3
Platelet count × 103/cmm	186 ± 74.33
HOMA score	3.48 ± 1.80
Steatosis	92 (74.2)
Etiology
Anti-HCV	53 (42.7)
NAFLD	35 (28.2)
NAFLD/diabetes	11 (8.8)
NASH	11 (8.8)
Cryptogenic	14 (11.3)
Histology (54)
Chronic hepatitis C	27 (50)
Cirrhosis cryptogenic	9 (16.6)
NAFLD	7 (12.9)
NASH	11 (20.3)
HFE mutations	53 (42.7)
H63D heterozygous	49 (39.5)
C282Y heterozygous	2 (1.6)
C282Y/H63D compound het	2 (1.6)

ULN: Upper limit of normal.