Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice

Figure 1 Effects of silibinin on proliferation and cell cycle progression in HuH7 xenograft tissue specimens. A: Silibinin inhibited Ki-67 expression; B: Silibinin inhibited Rb phosphorylation; C: Silibinin inhibited E2F1/DP1 complex formation; D: Silibinin increased p27/CDK4 complex formation; E: Silibinin inhibited Plk1 expression; F: Silibinin increased Chk1 expression; G: β-actin as internal control; H: Silibinin inhibited nuclear NF-κB content. ^aP < 0.05; ^bP < 0.01 vs control.