©2009 The WJG Press and Baishideng.
World J Gastroenterol. Apr 21, 2009; 15(15): 1809-1815
Published online Apr 21, 2009. doi: 10.3748/wjg.15.1809
Published online Apr 21, 2009. doi: 10.3748/wjg.15.1809
Table 2 Mechanisms of action of olive oil on fatty liver
| Mechanism | Component involved |
| Anti-inflammatory and immunomodulatory effects | Oleic acid |
| Phenolic compounds | |
| Anti-oxidants: | Oleic acid |
| Decrease lipid peroxidation | Phenolic compounds: hydroxytyrosol, oleuropein, caffeic acid, o-coumaric acid, vanillic acid, and 3,4-dihydroxyphenylethanol (3,4-DHPEA). |
| Decrease oxidative DNA damage | |
| Modulation of transduction pathways: | Oleic acid |
| Decreases arachidonic acid | Phenolic compounds: protocatecuic acid |
| Inhibits lipooxygenase | Hydroxytyrosol |
| Inhibits HMG-CoA reductase | Squalene |
| Decreases RAS activation | Squalene |
| Regulation of gene expression in liver regeneration: | Oleic acid |
| Minor compounds | |
| (Oleic acid inhibits δ6-desaturase which decreases PGE2 and inhibits liver regeneration) | |
| Change in membrane fluidity and membrane peroxidation (estrogen modulator, regulates G protein) | Oleic acid |
| Lignans |
- Citation: Assy N, Nassar F, Nasser G, Grosovski M. Olive oil consumption and non-alcoholic fatty liver disease. World J Gastroenterol 2009; 15(15): 1809-1815
- URL: https://www.wjgnet.com/1007-9327/full/v15/i15/1809.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.1809