Correlation of p53 over-expression and alteration in p53 gene detected by polymerase chain reaction-single strand conformation polymorphism in adenocarcinoma of gastric cancer patients from India

Table 3 Correlation between clinicopathological characteristics and p53 genetic alteration in patients with gastric adenocarcinoma

Factors	p53 alteration		n (%)	P1
	Negative (%)	Positive (%)
Age
< 40 yr	12 (14.29)	1 (5.26)	13 (12.62)	0.533
40-65 yr	55 (65.48)	15 (78.95)	70 (67.96)
> 65 yr	17 (20.23)	3 (15.79)	20 (19.42)
Gender				0.407
Male	62 (73.81)	16 (84.21)	78 (75.73)
Female	22 (26.19)	3 (15.79)	25 (24.27)
Cell differentiation				0.462
Well	9 (10.72)	2 (10.53)	11 (10.68)
Moderately	31 (36.90)	8 (42.11)	39 (37.86)
Poorly	44 (52.38)	9 (47.37)	53 (51.46)
Histology				0.522
Intestinal	35 (41.67)	10 (52.63)	45 (43.69)
Diffused	41 (48.81)	8 (42.11)	49 (47.57)
Undiff/mixed	8 (9.52)	1 (5.26)	9 (8.74)
Site				0.606
Cardiac	19 (22.62)	2 (10.53)	21 (20.39)
Fundus	14 (16.67)	2 (10.53)	16 (15.53)
Body	18 (21.43)	5 (26.32)	23 (22.33)
Antrum	33 (39.29)	10 (52.63)	43 (41.75)
Stage				0.813
I	26 (30.95)	6 (31.58)	32 (31.07)
II	32 (38.10)	6 (31.58)	38 (36.89)
III	21 (25.00)	6 (31.58)	27 (26.21)
IV	5 (5.95)	1 (5.26)	6 (5.83)

¹χ² test with Fisher’s test were used to test the frequency distribution of p53 alteration.

Undiff: Undifferentiated.