Iron homeostasis and H63D mutations in alcoholics with and without liver disease

Table 2 Comparison of HFE genotypes, with C282Y or H63D allelic frequencies in LDA vs NLDA subjects and a control population n (%)

	LDA (n = 78)	NLDA (n = 75)	Blood donors[34] (n = 133)
wt/wt	39 (50)	52 (68)	92 (69)
wt/H63D	31 (39.7)	19 (25.3)	27 (20)
wt/C282Y	3 (3.8)	2 (3.7)	7 (5)
H63D/H63D	3 (3.8)	2 (3.7)	6 (4)
C82Y/H63D	2 (2.5)	1 (1.3)	1 (1)
C282Y allelic frequency	0.032	0.02	0.03
H63D allelic frequency1	0.25	0.16	0.15
Any mutation1	39 (50)	24 (32)	41 (31)

wt: Wild type;

¹P = 0.02; There were no other statistically significant differences between the various groups.