Absence of Na+/sugar cotransport activity in Barrett’s metaplasia

Table 1 Uptake of AMG by duodenal, gastric fundic, and esophageal mucosal biopsies (mean ± SE)

	pmoles AMG mg wet wt	pmoles AMG/&mgr;g DNA
Duodenum	711.53 ± 121.63 (11)	249.84 ± 35.49 (12)
Fundus	41.04 ± 2.35 (12)b	36.20 ± 6.62 (12)b
Esophagus	45.52 ± 3.76 (3)a	12.10 ± 0.59 (3)d
Barrett’s	50.27 ± 4.32 (9)b	29.79 ± 5.77 (8)b

The number in parenthesis represents the biopsies tested. Three biopsies were taken from each tissue site of each patient.

^bP < 0.001 vs duodenum;

^aP < 0.02 vs duodenum;

^dP < 0.01 vs duodenum (Student's t-test). There was no significant difference (P > 0.05) between Barrett’s esophagus biopsies and biopsies of fundus or normal esophagus.