The blind men ‘see’ the elephant-the many faces of fatty liver disease

Figure 1 The pathogenesis of NAFLD has been disputed by many loud and long. The term “nonalcoholic fatty liver disease” is imprecisely defined; there is uncertainty regarding its pathogenesis. The elephant (NAFLD) has been interpreted by many and several possible etiologies and pathogenesis models have been assigned to it like ‘insulin resistance’, mitochondrial defects, adipokine imbalance, visceral fat, inflammatory cytokines and oxidant stress.