Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection

Figure 4 Adequate chemotaxis is necessary to control a viral infection. Specific cytotoxic T cells with active in vitro effector functionality are not able to control a viral infection if they do not express the appropriate chemokine receptor to reach the infected parenchyma. In a murine model of influenza virus infection, specific CCR5-expressing T cells were able to clear the virus while administration of specific CCR3-expressing T cells induced mouse death. CTLs: cytotoxic T lymphocytes.