Acute and persisting Th2-like immune response after fractionated colorectal γ-irradiation

Figure 3 Early Th1/Th2 polarization by fractionated irradiation protocol within 1 and 3 d of irradiation. Colorectal fractionated irradiation protocol induced suppression of Th1 cytokines (IFNγ and IFN-inducible genes (IP-10)) (A). Gene expression of the chemokine receptors CXCR3 and CCR4 (B) and transcription factors T-bet and Gata3 (C) implicated in the Th1/Th2 balance was analyzed one day after cumulative doses of 16 Gy, 36 Gy, 52 Gy and 3 d after 52 Gy in colon mucosa. Data are mean ± SE, ^aP < 0.05; ^bP < 0.01; ^cP < 0.005 vs control.