Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma

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Dec 14, 2008 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2008; 14(46): 7033-7058
Published online Dec 14, 2008. doi: 10.3748/wjg.14.7033

Table 1 Rodent models of intrahepatic cholangiocarcinoma constitutively overexpressing ErbB2/Neu in cancerous epithelium

Model	Tumor			ErbB2/Neu			Tyrosine phosphorylation	Ref.
Model	Development time	Incidence (%)	Classification	c-erbB-2/neu	mRNA	Protein	Tyrosine phosphorylation	Ref.
Furan rat model	> 1 yr	70-100	Intestinal-type cholangiocarcinoma	Wild-type/non-amplified	Increased	Increased	Increased	[63,64]
Thioacetamide rat model	16-22 wk	100	Intestinal-type cholangiocarcinoma	NA	NA	Increased	NA	[65]
P53 deficiency/CCl₄ mouse model	≥ 16 wk	40	Ductal cholangiocarcinoma	NA	NA	Increased	NA	[66]
Rat BDEneu orthotopic cell transplantation model	4 wk	100	Ductal cholangiocarcinoma	Mutated	Increased	Increased	Increased	[68,69]

NA: Not assessed.

Citation: Sirica AE. Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma. World J Gastroenterol 2008; 14(46): 7033-7058
URL: https://www.wjgnet.com/1007-9327/full/v14/i46/7033.htm
DOI: https://dx.doi.org/10.3748/wjg.14.7033