Dynamic localization of hepatocellular transporters in health and disease

Figure 3 Routes involved in trafficking of canalicular transporters. The trafficking of vesicles delivering Bsep (gray vesicles) or Mdr1/Mdr2 (white vesicles) from the site of synthesis to the canalicular domain is distinct. Mdr1 and Mdr2 are directly targeted to the canalicular membrane, whereas Bsep is indirectly targeted via a subapical, endosomal compartment, which allows the recycling of transporters (exocytic insertion/endocytic internalization). Once targeted, Mdr1 and Mdr2 are also able to recycle between the subapical compartment and the canalicular membrane.