Inhibitory effect of interferon-α-2b on expression of cyclooxygenase-2 and vascular endothelial growth factor in human hepatocellular carcinoma inoculated in nude mice

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Nov 28, 2008 (publication date) through Apr 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2008; 14(44): 6802-6807
Published online Nov 28, 2008. doi: 10.3748/wjg.14.6802

Table 1 Inhibitory effect of IFN α-2b on transplanted HCC in nude mice (mean ± SD, n = 8)

Groups	Dose (IU/d)	Tumor vol (mm³)	Tumor Wt (mg)	Inhibition ratio (%)
Control	0	3727.11 ± 745.53	1362.32 ± 272.12
Group A	10 000	2082.18 ± 416.43^a	983.85 ± 193.76^a	27.78
Group B	20 000	1521.43 ± 313.89^a^d	473.76 ± 92.57^a^d	65.22
Group C	40 000	1806.35 ± 363.71^a	686.06 ± 138.21^a	49.64

^aP < 0.01 vs control group;

^dP < 0.05 vs groups A and C.

Citation: Cao B, Chen XP, Zhu P, Ding L, Guan J, Shi ZL. Inhibitory effect of interferon-α-2b on expression of cyclooxygenase-2 and vascular endothelial growth factor in human hepatocellular carcinoma inoculated in nude mice. World J Gastroenterol 2008; 14(44): 6802-6807
URL: https://www.wjgnet.com/1007-9327/full/v14/i44/6802.htm
DOI: https://dx.doi.org/10.3748/wjg.14.6802

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