Practical guidelines for diagnosis and early management of drug-induced liver injury

Table 4 Diagnostic methods used for diagnosis of drug-induced liver injury during the last decade

Drug	Type2	Criteria	Country	Yr
Acetoaminophen1	H	None	Italy	2008
Dexketoprofen trometamol	H	None	Spain	2008
Anabolic-androgenic steroids	C	None	Mexico	2008
Quizalofop-p-ethyl	M	CIOMS/RUCAM	Greece	2007
Amoxicillin/clavulanate	M	None	USA	2007
Fenofibrate	H	None	Poland	2007
INH/RMP/PZA	M	None	USA	2007
Risperidone, Quetiapine	C	NADRPS	USA	2007
Clindamycin	C	NADRPS	Turkey	2007
Bupropion	M	CIOMS/RUCAM, M&V	USA	2007
Flutamide, Cyproterone	H	CIOMS/RUCAM	Spain	2007
Levothyroxine	H	DDW-J	Japan	2007
5-Fluorouracil1	H, M	NADRPS	New Zealand	2007
Sairei-to	H	LMT3	Japan	2007
Terbinafine	H	NADRPS, CIOMS/RUCAM	USA	2007
Ezetimide	H	None	USA	2007
Terbinafine	M	None	USA	2007
Infliximab1	H, C	None	Colombia	2007
Methylenedioxymethamphetamine	M	None	Canada	2006
Methylprednisolone	H	NADRPS	Turkey	2006
Shen-min	H	CIOMS/RUCAM	China	2006
Nimesulide	H	None	Italy	2006
Nevirapine	H	None	France	2006
Sirolimus	H	None	Poland	2005
Amiodarone	H	None	Japan	2005
Proguanil, Chloroquine	M	CIOMS/RUCAM	France	2005
Sulpyrine, Clarithromycin	H	None	Japan	2005
Glimepiride	C	None	Greece	2005
Flucloxacillin	M	None	Australia	2005
Sulbactam/ampicillin	C	NADRPS	Turkey	2004
Hydrochlorothiazide	M	NADRPS	Israel	2004
Ketoconazole	M	Original criteria	Korea	2003
Nimesulide	M	None	Turkey	2003
Ramipril	C	None	Canada	2003
Gemcitabine	M	None	USA	2003
Amoxicillin/clavulanate, Ciprofloxacin	H	Medline	USA	2003
Bupropion, Carbimazole	H	NADRPS	Singapole	2003
Ciprofloxacin	H	CIOMS/RUCAM	Germany	2003
6-Thioguanine	H	None	USA	2003
Terfenadine, Oxatomide	M	None	Japan	2002
Pioglitazone	M	None	USA	2002
Danazol	H	None	Japan	2001
Levofloxacin	H	None	USA	2001
Captopril1	M	None	Israel	2001
Pioglitazone	H	None	Japan	2001
Celecoxib	M	None	USA	2001
Nimesulide	M	WHO database	Switzerlamd	2001
Flutamide1	H	CIOMS/RUCAM, M&V	Spain	2001
Risperidone	C	None	Germany	2001
Zafirlukast	H	None	USA	2000
Troglitazone	H	None	USA	2000
Stavudine1	H	None	USA	2000
Bentazepam1	M	None	Spain	2000
Rosiglitazone	H	None	USA	2000
Nitrofurantoin	M	Non	Israel	1999
Nimesulide1	H, M	CIOMS/RUCAM	Belgium	1998
Omeprazole	H	WHO database	Switzerlamd	1998
Troglitazone	M	None	USA	1998
Acarbose1	H	None	Japan	1998
Benzylpenicillin	H	CIOMS/RUCAM	Switzerland	1997
Terbinafine	M	None	France	1997

¹Cases reported in multiple numbers, not in a single case, are summarized.

²Type of liver injury. H: hepatocellular; C: cholestatic; M: mixed.

³LMT, Lymphocyte migration test.