Practical guidelines for diagnosis and early management of drug-induced liver injury

Table 1 Common causative agents of drug-induced liver injury with fatalities fatalities

Drug	n (%)
Acetaminophen	305 (16.9)
Anti-HIV1
Stavudine, didanosine, nevirapine, zidovudine	303 (16.8)
Troglitazone	211 (11.7)
Anticonvulsants (valproate, phenytoin)	187 (10.3)
Anti-cancer	223 (12.3)
Flutamide	59 (3.3)
Cyclophosphamide	56 (3.1)
Methotrexate	55 (3.0)
Cytarabine	53 (2.9)
Antibiotics	158 (8.7)
Trovafloxacin	57 (3.2)
Sulfa/trimethoprim	52 (2.9)
Clarithromycin	51 (2.8)
Anesthetic
Halothane	85 (4.8)
Anti-tuberculosis
Isoniazid	57 (3.2)
Diclofenac	56 (3.1)
Oxycodone	56 (3.1)

¹human immunodeficiency virus.