Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma

Table 3 The 11 genes for which expression levels differed between HBV- and HCV-associated HCC

Gene name	Symbol1	Accession2	Fold change3	HBV:HCV4
7 genes up-regulated in HBV-associated HCC
Ribosomal protein S5	RPS5	NM_001009	6.35	2.38
Keratin 8	KRT8	NM_002273	5.68	3.19
CASP8 and FADD-like apoptosis regulator	CFLAR	Y14039	2.86	2.09
ATP synthase, H+transporting, mitochondrial F0 complex, subunit b, isoform 1	ATP5F1	X60221	4.11	3.52
Insulin-like growth factor binding protein 2 (36 kDa)	IGFBP2	NM_000597	3.37	2.49
Mitogen-activated protein kinase kinase kinase 5	MAP3K5	NM_005923	3.76	2.33
Matrix metalloproteinase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase)	MMP9	NM_004994	7.43	3.74
4 genes up-regulated in HCV-associated HCC
Vimentin	VIM	NM_003380	8.61	0.28
Actin-β	ACTB	X00351	4.13	0.37
Glyceraldehyde-3-phosphate_dehydrogenase	GAPD	NM_002046	5.27	0.29
CD58 antigen, (lymphocyte function-associated antigen 3)	CD58	NM_001779	4.68	0.31

¹Symbol in LocusLink database;

²GeneBank accession number;

³Fold change, ratio of mean expression values in HBV- or HCV-associated cases (cancer cells vs non-cancerous cells);

⁴HBV:HCV ratio of mean expression values (HBV positive cases to HCV positive cases).