Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers

Table 2 Time-points of 5-yr overall survival and disease free survival according to each parameter and P-value of univariate survival analysis with log-rank test

Parameter	5-yr DFS (%)	5-yr OS (%)	Log-rank P
Overall	54	57.7	-
Sex			0.77
Male	50.6	56.3
Female	56.9	58.5
Age (yr)			0.3
< 65	55.7	59.7
≥ 65	52.1	55.3
CEA			0.09
< 5 ng/mL	59.7	65.1
≥ 5 ng/mL	48.2	50.0
AJCC staging			< 0.001
Stage 1	68.6	75.0
Stage 2	81.2	86.9
Stage 3	39.2	41.3
Stage 4	0	0
Tumor size			0.38
T 0-1	61.9	72.0
T 2-3	52.4	55.1
Nodal status			< 0.001
N0	73.1	79.1
N1	42.6	46.1
N2	21	21.1
Metastatic status			< 0.001
M0	61.1	65.2
M1	0	0
Location			0.03
Colon	61.6	65.8
Rectum	46.1	49.4
Differentiation			0.06
Well	61.9	62.0
Moderate	49.4	49.5
Poor	34.2	34.3
Staining localization			0.09
Nuclear	69.2	73.3
Non-nuclear	50.5	54.1
Staining intensity			0.61
Weak to moderate	60.9	65.4
Strong to very strong	50.7	54.1
OSD			< 0.001
Low (< 75%)	34.7	63.4
High (≥ 75%)	60.5	40.0
NSD			0.59
Low (< 75%)	51.1	55.8
High (≥ 75%)	56.5	59.3

OSD: Overall staining density; NAD: Nuclear staining density; OS: Overall survival; DFS: Disease free survival.