Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers

Table 1 Demographic data of the study population and association of studied parameters and overall staining density, n (%)

Parameter	Cases	Overall staining density		P
		Low	High
Sex
Male	80 (49.3)	18 (45.0)	62 (50.8)	0.52
Female	83 (50.6)	22 (55.0)	60 (49.2)
Age (yr)
< 65	87 (53.4)	21 (52.5)	66 (53.7)	0.90
> 65	76 (46.6)	19 (47.5)	57 (47.3)
CEA
< 5 ng/mL	83 (50.9)	25 (62.5)	58 (47.1)	0.09
≥ 5 ng/mL	80 (49.1)	15 (37.5)	65 (52.9)
AJCC staging
Stage 1	20 (12.3)	4 (10.0)	16 (13.0)	0.004
Stage 2	61 (37.4)	11 (27.5)	50 (40.7)
Stage 3	63 (38.7)	14 (35.0)	49 (39.8)
Stage 4	19 (11.7)	11 (27.5)	8 (6.5)
Tumor size
T 0-1	25 (15.3)	5 (12.5)	20 (16.3)	0.57
T 2-3	138 (84.7)	35 (87.5)	103 (83.7)
Nodal status
N0	86 (52.8)	17 (42.5)	69 (56.1)	0.02
N1	39 (23.9)	7 (17.5)	32 (26.0)
N2	38 (23.3)	16 (40.0)	22 (17.8)
Metastatic status
M0	144 (88.3)	29 (72.5)	115 (93.5)	< 0.001
M1	19 (11.7)	11 (27.5)	8 (6.5)
Differentiation
Well	83 (50.9)	19 (47.5)	64 (52.0)	0.02
Moderate	60 (36.8)	11 (27.5)	49 (39.8)
Poor	20 (12.3)	10 (25.0)	10 (8.1)
Staining localization
Nuclear	122 (50.3)	19 (47.5)	63 (51.2)	0.68
Non-nuclear	31 (49.6)	21 (52.5)	60 (48.8)
Staining intensity
Weak to moderate	54 (33.1)	18 (45.0)	34 (28.1)	0.05
Strong to very strong	109 (66.9)	22 (55.0)	87 (71.9)
NSD
Low (< 75%)	101 (47.2)	33 (82.5)	44 (35.8)	< 0.001
High (≥ 75%)	62 (52.8)	7 (17.5)	9 (64.2)