Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis

Table 3 Predictive factors for IPF development¹

Factor	Univariate analysis				Multivariate analysis1
	Category	Hazard ratio	95% CI	P	Category	Hazard ratio	95% CI	P
Age (yr)	< 55/≥ 55	1/11.78	3.52-39.37	< 0.001	< 55/≥ 55	1/12.52	3.52-44.59	< 0.001
Smoking index1	< 20/≥ 20	1/4.56	1.52-13.61	0.007	< 20/≥ 20	1/5.90	1.95-17.82	0.002
Liver staging (fibrosis)	Non-LC/LC	1/3.67	1.29-10.48	0.015	Non-LC/LC	1/3.00	1.04-8.64	0.042
Sex	Male/Female	1/0.45	0.13-1.62	0.223
Platelet (x 104/mm3)	< 15/≥ 15	1/0.47	0.10-2.23	0.341
γGTP (IU/L)	< 110/≥ 110	1/1.95	0.41-9.31	0.405
Total alcohol intake1	< 200/≥ 200	1/1.50	0.50-4.48	0.467
AST (IU/L)	< 76/≥ 76	1/1.16	0.30-4.53	0.834
ALT (IU/L)	< 100/≥ 100	1/1.05	0.29-3.74	0.946

Data are number of patients or mean ± SD.

¹Smoking index = (package/d) × year. Total alcohol intake and smoking index indicate the sum of before and after first consultation