Primary signet ring cell carcinoma of the appendix: A rare case report and our 18-year experience

Table 1 Clinical characteristics, tumor features, treatment, and survival of 15 out of 3389 patients who underwent appendectomy over an 18-year period

Patient’s No.	Age /sex	Symptom	Type of treatment	Histology	Grade	Stage	Tumor marker elevated	Surgery	Additional treatment	Metastatic sites	Relapse
1	62/F	No	EL	Mucinous epithelial tumor	Low grade	D	CEA	RHC, TAH, BSO, Appendicectomy	Chemotherapy (CP)	Ovary, Peritoneum, Omentum	No
2	58/F	Pain	EM	Mucinous epithelial tumor	Low grade	D	-	RHC, Appendicectomy	No	Rupture of appendix	No
3	43/F	Pain	EL	Mucinous adenocarcinoma	WD	L	NA	BSO, Appendicectomy	No	No	Loss
4	43/M	Pain	EL	Mucinous adenocarcinoma	Low grade	L	NA	BSO, Appendicectomy	No	No	No
5	69/F	Pain	EL	Mucinous adenocarcinoma	WD	D	NA	TAH, BSO, Appendicectomy	No	Ovary, Peritoneum	Loss
6	68/M	Pain	EM	Mucinous adenocarcinoma	WD	L	-	RHC, Appendicectomy	No	No	No
7	58/M	Pain	EM	Mucinous adenocarcinoma	WD	D	-	Appendicectomy Omentectomy	No	Omentum	Yes
8	61/M	Pain	EM	Mucinous adenocarcinoma	WD	L	-	RHC, Appendicectomy	Chemotherapy (FL)	Lung	Yes
9	63/F	No	EL	Mucinous adenocarcinoma	WD	D	-	TAH, BSO, Appendicectomy	Chemotherapy (FOLFOX)	Ovary, Peritoneum, Omentum	No
10	59/M	No	EL	Mucinous adenocarcinoma	WD	L	-	RHC, Appendicectomy	No	No	No
11	42/M	Pain	EM	Colonic type adenocarcinoma	PD	L	NA	RHC, Appendicectomy	No	Liver, Peritoneum	Yes
12	73/M	Pain	EM	Colonic type adenocarcinoma	MD	R	CEA	RHC, Appendicectomy	No	No	Yes (colon cancer)
13	62/F	Abdominal distension	EL	Colonic type adenocarcinoma	MD	L	CEA	RHC, Appendicectomy	No	No	No
14	67/M	Pain	EM	Colonic type adenocarcinoma	MD	L	NA	RHC, Appendicectomy	No	No	No
15	67/F	Abdominal distension	EL	Signet ring cell carcinoma		D	-	Appendicectomy, BSO	Chemotherapy (FOLFOX)	Ovary, Peritoneum, Omentum	-

EL: Elective; EM: Emergency; WD: Well differentiated; MD: Moderately differentiated; L: Localized; R: Regional; D: Distant; NA: Not available; RHC: Right hemicolectomy; TAH: Transabdominal abdominal hysterectomy; BSO: Bilateral salpingo-oophorectomy; CP: Cyclophosphamide/cisplatin; FL: 5-fluorouracil/leucovorin; FOLFOLX: Oxaliplatin/5-fluorouracil/leucovorin.