Neuroendocrine tumors of the gastro-entero-pancreatic system

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Sep 21, 2008 (publication date) through Apr 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2008; 14(35): 5377-5384
Published online Sep 21, 2008. doi: 10.3748/wjg.14.5377

Table 5 Results of studies of molecularly targeted agents in patients with neuroendocrine tumours[54,55]

Agent	Response rate (%)	PFS rate (%)/Duration
VEGF monoclonal antibody
Bevacizumab[56]	18	95 at 18 wk
mTOR inhibitor
RAD001 (everolimus)	13	71 at 24 wk
Temsirolimus[57]	5.6	50 at 6 mo
VEGF TKI
Sunitinib	10	Median, 42 wk
Vatalanib	In progress	(time to progression)
Sorafenib	In progress
Pazopanib	In progress
PDGFR/Kit/Abl inhibitor
Imatinib[58]	4	Median, 5.9 mo
EGFR inhibitor
Gefitinib	4	61 (carcinoids) and 31 (pancreatic tumor) at 6 mo
Other
Bortezomib[59]	0	Median, 3 mo
		(Time to treatment failure)

PFS: Progression free survival.

Citation: Massironi S, Sciola V, Peracchi M, Ciafardini C, Spampatti MP, Conte D. Neuroendocrine tumors of the gastro-entero-pancreatic system. World J Gastroenterol 2008; 14(35): 5377-5384
URL: https://www.wjgnet.com/1007-9327/full/v14/i35/5377.htm
DOI: https://dx.doi.org/10.3748/wjg.14.5377